When you start the game, you don’t want to stick near the plane for too long. Scavenge everything you can from the area and then move on.
Be sure to build shelter for yourself.
Explore the caves.
Eat before you go to sleep. If you can’t sleep during the night, this might be a sign that mutants are nearby.
Try to make sure you always have some extra food with you, just in case.
A houseboat is effective shelter because you can spend the night offshore.
During the day, you can use a burning effigy to drive away enemies, although they may return.
Mutant patrols often move in particular patterns. If you find an area with heavy patrols, try setting traps along their paths.
You’ll want to craft the Warmsuit as soon as you can. Since it will keep you warm, it reduces how often you’ll need to build a fire. Fires attract enemies, so this is quite valuable.
If you don’t want to fight, you can hide from enemies.
Use the environment to your advantage. For example, if a mutant runs into a firepit, they will catch on fire.
Armor can protect you, but it will also be taken a sign of a threat. If the mutants aren’t hostile toward you yet, consider avoiding the armor until they’re already hostile, or you’ll risk attacks.